Endocrine Abstracts

Introduction: Over the past decades diabetes emerged as epidemic dimension due to person’s genetic pre disposition and environmental condition. Despite significant advancement in the development of oral hypoglycemic agents, an ideal drug for treating T2DM and its complication is still a distant reality. Hyperglycemia has a variety of toxic effects, including elevated generation of ROS nitrosative stress and inflammation. This work attempts to explore the role of oxidative...

Background: Transsphenoidal surgery is the primary therapy in majority of Acromegaly patients with GH-secreting somatotroph adenomas. Reported outcomes of surgery show an initial remission rate of 40–50% for macroadenomas and >85% for microadenomas. Rates of hypopituitarism following endoscopic pituitary decompression vary between 5 and 25%. Invasion of cavernous sinus indicates the tumour is unlikely to be resectable.Methods: We audited the res...

Introduction: Medullary thyroid carcinoma (MTC) is a rare thyroid malignancy originating from parafollicular C-cells. It accounts for 5% of all thyroid carcinomas.Methods: A retrospective registry-based analysis of demography, clinical manifestation, genetics, management, and outcome of pathologically proven MTC cases presented in a tertiary care hospital in India was done.Results: Among 71 evaluated cases, the mean age of presenta...